Respiratory manifestationsRespiratory manifestations of hypophosphatasia can be life-threatening. Breathing complications may consist of anything from progressive pneumonia to respiratory failure as a consequence of reduced thoracic volume and pulmonary hypoplasia. Respiratory failure is the most common cause of death in infants with hypophosphatasia.

In patients with hypophosphatasia, respiratory manifestations can lead to:
  • Insufficient respiration that requires intubation, mechanical ventilation and/or oxygen
  • Lung inflammation and respiratory failure
Lung insufficiency that requires a tracheostomy tube
Lung insufficiency that requires a tracheostomy tube 
Hickman Simmons J 2013
Hypomineralisation of ribs
Hypomineralisation of ribs 
Rodriguez E et al. 2012

Leung EC et al. JIMD Rep 2013; 11: 73-78.
Hickman Simmons, J. Best Practices In: Recognizing and Diagnosing Hypophosphatasia. Clinical Endocrinology News. 2013; 1-8.
Rodriguez E et al. Pediatr Pulmonol. 2012; 47 (9):917-922
Silver et al. MM Pediatr Pathol 1988; 8: 483-493.
Whyte MP et al. N Engl J Med 2012; 366: 904-913.


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SYMPTOMS AND CONDITIONS
ASSOCIATED WITH HYPOPHOSPHATASIA

COMMON SYMPTOMS AND CONDITIONS THAT
CAN BE CAUSED BY HYPOPHOSPHATASIA READ MORE

THE ALP CALCULATOR
– DIAGNOSTIC TOOL

LOW ALP ACTIVITY KEY TO DIAGNOSIS READ MORE


IMPORTANT DIFFERENTIAL DIAGNOSES

IMPORTANT DIFFERENTIAL 
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