Hypophosphatasia also affects the teethMany patients with hypophosphatasia lose their deciduous teeth significantly earlier than normal, sometimes as young as between one and three years old. They often lose these teeth with the whole root and without gum inflammation. This applies primarily to the front teeth in the lower jaw, but all deciduous teeth can be affected. Early loss of deciduous teeth can be the principal sign of the disease in many patients with all the various forms of HPP.

There is also a risk that adults with hypophosphatasia will be affected by dental problems. In patients with hypophosphatasia who are not diagnosed until adulthood, the periodontal element of the disease will often have been pronounced since childhood.

Tooth-loosening of intact milk teeth with root
Tooth-loosening of intact deciduous teeth with root
Reibel A et al. 2009


Other tooth-related problems may include:  
  • Enlarged pulp chambers and root canals
  • Abnormal enamel and dentin formation
  • Deviations in tooth shape, structure and eruption
If the patient only has dental problems and no other symptoms of the disease, it may be mildest form of the disease, which is called odontohypophosphatasia.

Kjellman M et al. Int J Oral Surg 1973; 2: 152-158.
Lundgren T et al. Scand J Dent Res 1991; 99: 357-364.
Olsson A et al. J Oral Pathol Med 1996; 25: 343-347.
Reibel A et al. Orphanet J Rare Dis 2009; 4: 6.
Van den Bos T et al. J Dent Res 2005; 84: 1021-1025.



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SYMPTOMS AND CONDITIONS
ASSOCIATED WITH HYPOPHOSPHATASIA

COMMON SYMPTOMS AND CONDITIONS THAT
CAN BE CAUSED BY HYPOPHOSPHATASIA READ MORE

THE ALP CALCULATOR
– DIAGNOSTIC TOOL

LOW ALP ACTIVITY KEY TO DIAGNOSIS READ MORE


IMPORTANT DIFFERENTIAL DIAGNOSES

IMPORTANT DIFFERENTIAL 
DIAGNOSES/CONDITIONS READ MORE
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